BOHEMIA is a consortium led by ISGlobal and funded by Unitaid. It aims to explore ivermectin as an innovative and complementary tool to reduce malaria transmission through a mass drug administration (MDA) trial. The MDA is being implemented in Mozambique by the Centro de Investigação em Saúde de Manhiça (CISM), and in Kenya by the Kenya Medical Research Institute in collaboration with the KEMRI | Wellcome Trust research program.
The Barcelona Institute for Global Health, ISGlobal, is a cutting-edge institute with the capacity to address global public health challenges through research, knowledge translation and education. It has a broad research portfolio in communicable and non-communicable diseases and environmental factors. ISGlobal is known for its long history and achievements in the field of malaria, and is a WHO Collaborating Center for Malaria Control, Elimination and Eradication.
Centro de Investigação em Saúde de Manhiça (CISM)
The Manhiça Health Research Centre (CISM), in Mozambique, was created in 1996 as a collaborative program between the Spanish Agency for International Cooperation for Development (AECID), the Ministry of Health in Mozambique, the Fundació Clínic per a la Recerca Biomèdica (FCRB) and the National Health Institute to promote and conduct biomedical research in priority areas aimed at improving the health of the most vulnerable populations. For more than two decades, CISM, through its research activities, has sought to find solutions both in the area of malaria treatment, diagnosis and prevention. With a team of researchers of recognized national and international merit, the Centre positions itself at the highest levels of malaria research, covering clinical-epidemiological research and clinical trials of new drugs and vaccines, as well as monitoring of morbidity, mortality and transmission intensity of this disease. The CISM has the role of developing and coordinating activities in the field in Mozambique.
Ifakara Health Institute (IHI)
The Ifakara Health Institute (IHI), in Tanzania, is a leading research organization in Africa, with strong track records in developing, testing and validating innovations for health. The institute’s work spans across a wide spectrum of sciences including biomedical and ecological sciences, intervention studies, health-systems research, monitoring and evaluation and policy translation. IHI hosts the clinical trial in Tanzania – one of the two eco-epidemiological settings in east and southern Africa.
University Hospital Bern
The Inselspital, University Hospital Bern is the largest public hospital group in Switzerland and is associated with University of Bern. It holds a key position in research and teaching in the Swiss healthcare system, enjoys an excellent international reputation as an incubator for innovation and venue of the science community.
University of Oxford
The Centre for Tropical Medicine and Global Health is a world leading Centre within the Nuffield Department of Clinical Medicine, University of Oxford, comprised of research groups who are permanently based in Africa and Asia as well as across two sites in Oxford. It’s research ranges from clinical studies to behavioural sciences, with capacity building integral to all of our activities. Through their facilities in Kenya, they are engaged as a core laboratory and training for PCR, cross social sciences package, and leading entomology for BOHEMIA.
Virginia Tech fulfils its role as a land-grant university by fostering a collaborative environment that integrates technology into all disciplines. The university is home to the Virginia-Maryland College of Veterinary Medicine, a leading biomedical teaching and research centre focused on the development and delivery of a One Health education. The college conducts a broad spectrum of basic/molecular and translational/applied research which aims to better understand diseases that afflict both humans and animals, and to develop vaccines and
KEMRI Wellcome Trust Research Programme (KWTRP)
The KEMRI Wellcome Trust Research Programme (KWTRP) is based within the KEMRI Centre for Geographic Medical Research – (Coast). KWTRP’s core activities are funded by the Wellcome Trust. KWTRP conducts integrated epidemiological, social, laboratory and clinical research in parallel, with results feeding into local and international health policy. Its research platforms include state-of-the-art laboratories, a demographic surveillance system covering a quarter of a million residents, partnership with Kilifi County Hospital in health care and hospital surveillance, a clinical trials facility, a vibrant engagement programme and a dedicated training facility.
Kenya Medical Research Institute (KEMRI)
The Kenya Medical Research Institute (KEMRI) is a State Corporation established in Kenya in 1979 through the Science and Technology (Repealed) Act, Cap 250 of the Laws of Kenya operated under the Science Technology and Innovation Act, 2013 as the national body responsible for carrying out research in human health in Kenya. Currently, KEMRI operates under Legal Notice No. 35 of March 2021. KEMRI has grown from its humble beginning over 40 years ago to become a regional leader in human health research. The Institute currently ranks as one of the leading Centres of excellence in health research both in Africa as well as globally.
Databrew is an agency that helps organizations and individuals to better explore, understand, and use information. It specializes in data-driven consulting, data management, instruction/training, dashboard construction, and data visualization. Databrew strives to empower its clients by providing analytical approaches for asking the right questions and tools for uncovering answers, as well as teaching context and challenging students to think and learn on their own. Databrew is in charge of building a data management system to handle all aspects of the Bohemia project’s “data lifecycle” – from data collection and storage to analysis and dissemination – using custom-built, open-source software tools.
Camargo Pharmaceutical Services helps clients solve complex challenges through rigorous science and creative development strategies. They offer an integrated portfolio of drug development solutions from concept through commercialization to bring life-changing medicines to market faster and more cost-effectively. Camargo partnered with ISGlobal on the BOHEMIA Project to provide strategic drug development and clinical trial design expertise aimed at ensuring safe and effective use of ivermectin to reduce malaria transmission.
This pharmacovigilance and drug safety service provider offers expertise in the areas of clinical trial as well as post authorisation pharmacovigilance operations, system management and support services. It supports existing commercial pharmaceutical companies, commercial sponsors, academia, biotechnology companies as well as CROs. IntuVigilance services include drug safety, pharmacovigilance, cosmetovigilance, nutravigilance, materiovigilance and veterinary services. Intu Vigilance is the drug safety department on the BOHEMIA programme providing full-service drug safety including medical monitoring.
Bridges to Development
Bridges to Development is a non-profit organisation founded in 2018 and based in Europe and the US. Their mission is to make the most of the world’s significant progress to date towards a stronger and more resilient future. Their work focuses on bridging the gaps in equitable access and opportunity in low and middle-income countries, especially for women and girls. Bridges is partnering with the BOHEMIA team to ensure lessons learned from the neglected tropical diseases (NTD) experience with ivermectin can help inform the BOHEMIA project and there is good coordination with NTD partner organizations.
International Public Health Advisors
International Public Health Advisors (IPHA) works at the intersection of international development, public health, and public/private sector engagement. IPHA is an active member of the malaria community. Since the inception of the Roll Back Malaria (RBM) Partnership, IPHA has led several key initiatives and has provided consulting services to many organizations funding and implementing programmes for malaria control and elimination. IPHA’s involvement in the BOHEMIA project will consist of technical assistance to mapping of Key Opinion Leaders, development of BOHEMIA Partners Forums, dissemination of results and policy pertaining to post project adaptation and procurement strategy.
About our donor
Unitaid brings the power of new medical discoveries to the people who most need them and helps set the stage for large-scale introduction of new health products by collaborating with governments and partners such as PEPFAR, the Global Fund and WHO. Unitaid invests in new ways to prevent, diagnose and treat diseases including HIV/AIDS, hepatitis C, tuberculosis and malaria more quickly, affordably and effectively. A growing number of their programs address more than one disease, maximizing effectiveness of health systems.